A Five-Gene Signature for Recurrence Prediction of Hepatocellular Carcinoma Patients
نویسندگان
چکیده
منابع مشابه
A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients.
Metastasis-related recurrence often occurs in hepatocellular carcinoma (HCC) patients who receive curative therapies. At present, it is challenging to identify patients with high risk of recurrence, which would warrant additional therapies. In this study, we sought to analyze a recently developed metastasis-related gene signature for its utility in predicting HCC survival, using 2 independent c...
متن کاملIdentification and validation of a novel gene signature associated with the recurrence of human hepatocellular carcinoma.
PURPOSE To improve the clinical management of human hepatocellular carcinoma (HCC) by accurate identification, at diagnosis, of patients at risk of recurrence after primary treatment for HCC. EXPERIMENTAL DESIGN Two clinicopathologic variables available at diagnosis, vascular invasion and cirrhosis, together with molecular profiling using Affymetrix human HG-U133A and HG-U133B oligonucleotide...
متن کاملMolecular-based prediction of early recurrence in hepatocellular carcinoma.
BACKGROUND/AIMS Hepatocellular carcinoma (HCC) has a very poor prognosis, due to the high incidence of tumor recurrence. As the current morphological indicators are often insufficient for therapeutic decisions, we sought to identify additional biologic indicators for early recurrence. METHODS We analyzed gene expression using a PCR-based array of 3,072 genes in 100 HCC patients. Informative g...
متن کاملMolecular and Cellular Pathobiology A Unique Metastasis Gene Signature Enables Prediction of Tumor Relapse in Early-Stage Hepatocellular Carcinoma Patients
Metastasis-related recurrence often occurs in hepatocellular carcinoma (HCC) patients who receive curative therapies. At present, it is challenging to identify patients with high risk of recurrence, which would warrant additional therapies. In this study, we sought to analyze a recently developedmetastasis-related gene signature for its utility in predictingHCC survival, using 2 independent coh...
متن کاملGene expression-based recurrence prediction of hepatitis B virus-related human hepatocellular carcinoma.
PURPOSE The poor prognosis of hepatocellular carcinoma (HCC) is, in part, due to the high rate of recurrence even after "curative resection" of tumors. Therefore, it is axiomatic that the development of an effective prognostic prediction model for HCC recurrence after surgery would, at minimum, help to identify in advance those who would most benefit from the treatment, and at best, provide new...
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ژورنال
عنوان ژورنال: BioMed Research International
سال: 2020
ISSN: 2314-6141,2314-6133
DOI: 10.1155/2020/4037639